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Prof. Dr. Frederick Klauschen

Prof. Dr. Frederick Klauschen

Research Group Lead / Charité

Research Grouplead | BIFOLD

Director | Pathologisches Institut, Ludwig-Maximilian-Universität München

Professor, Senior Consultant Pathologist and Associate Director | Charité Universitätsmedizin Berlin, Institute of Pathology

2012 Novartis Pathology-Oncology Award
2011 Human Frontier Science Program Young Investigator Award
2004 NIH Postdoctoral Fellowship Award

Systems biological integration of proteogenomic profiles and histological images through bioinformatics and machine learning with the goal to better understand and predict pathological mechanisms in tumors and finally, to better diagnose and treat cancer.

  • German Pathological Society
  • International Academy of Pathology
  • German Physical Society

Marvin Sextro, Gabriel Dernbach, Kai Standvoss, Simon Schallenberg, Frederick Klauschen, Klaus-Robert Müller, Maximilian Alber, Lukas Ruff

xCG: Explainable Cell Graphs for Survival Prediction in Non-Small Cell Lung Cancer

November 12, 2024
https://ui.adsabs.harvard.edu/link_gateway/2024arXiv241107643S/doi:10.48550/arXiv.2411.07643

Jonas Dippel, Niklas Prenißl, Julius Hense, Philipp Liznerski, Tobias Winterhoff, Simon Schallenberg, Marius Kloft, Oliver Buchstab, David Horst, Maximilian Alber, Lukas Ruff, Klaus-Robert Müller, Frederick Klauschen

AI-Based Anomaly Detection for Clinical-Grade Histopathological Diagnostics

October 18, 2024
https://ai.nejm.org/doi/full/10.1056/AIoa2400468

Philipp Jurmeister, Maximilian Leitheiser, Alexander Arnold, Emma Payá Capilla, Liliana H Mochmann, Yauheniya Zhdanovic, Konstanze Schleich, Nina Jung, Edgar Calderon Chimal, Andreas Jung, Jörg Kumbrink, Patrick Harter, Niklas Prenißl, Sefer Elezkurtaj, Luka Brcic, Nikolaus Deigendesch, Stephan Frank, Jürgen Hench, Sebastian Försch, Gerben Breimer, Ilse van Engen van Grunsven, Gerben Lassche, Carla van Herpen, Fang Zhou, Matija Snuderl, Abbas Agaimy, Klaus-Robert Müller, Andreas von Deimling, David Capper, Frederick Klauschen, Stephan Ihrler

DNA methylation profiling of salivary gland tumors supports and expands conventional classification

September 25, 2024
https://doi.org/10.1016/j.modpat.2024.100625

Gabriel Dernbach, Daniel Kazdal, Lukas Ruff, Maximilian Alber, Eva Romanovsky, Simon Schallenberg, Petros Christopoulos, Cleo-Aron Weis, Thomas Muley, Marc A. Schneider, Peter Schirmacher, Michael Thomas, Klaus-Robert Müller, Jan Budczies, Albrecht Stenzinger, Frederick Klauschen

Dissecting AI-based mutation prediction in lung adenocarcinoma: A comprehensive real-world study

September 14, 2024
https://doi.org/10.1016/j.ejca.2024.114292

Jonas Dippel, Niklas Prenißl, Julius Hense, Philipp Liznerski, Tobias Winterhoff, Simon Schallenberg, Marius Kloft, Oliver Buchstab, David Horst, Maximilian Alber, Lukas Ruff, Klaus-Robert Müller, Frederick Klauschen

AI-based Anomaly Detection for Clinical-Grade Histopathological Diagnostics

June 21, 2024
https://doi.org/10.48550/arXiv.2406.14866

News
Machine Learning| Oct 24, 2024

AI in medicine: new approach for more efficient diagnostics

Researchers from LMU, BIFOLD, and Charité have developed a new AI tool that uses imaging data to also detect less frequent diseases of the gastrointestinal tract. In contrast to conventional models, the new AI only needs training data from common findings to detect deviations.

News
Machine Learning| Nov 30, 2022

AI facilitates breakthrough in cancer diagnostics

So-called sinonasal undifferentiated carcinomas (SNUCs) are extremely difficult to diagnose. An interdisciplinary team of researchers has developed an AI tool that reliably distinguishes tumors on the basis of chemical DNA modifications 

BIFOLD Update| Aug 06, 2020

An overview of the current state of research in BIFOLD

Since the official announcement of the Berlin Institute for the Foundations of Learning and Data in January 2020, BIFOLD researchers achieved a wide array of advancements in the domains of Machine Learning and Big Data Management as well as in a variety of application areas by developing new Systems and creating impactfull publications. The following summary provides an overview of recent research activities and successes.