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Prof. Dr. Roland Schwarz

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University of Cologne

Prof. Dr. Roland Schwarz

Fellow

Fellow | BIFOLD

Principle Investigator | Professor for Computational Cancer Biology, Center for Integrative Oncology (CIO), Cancer Research Center
Cologne Essen (CCCE), University of Cologne, Germany

2016 Prize of the Berlin Brandenburg Academy of Science for Cancer Research
2010 – 2016 Junior Research Fellowship, Wolfson College, University of Cambridge
2013 Finalist EMBL Outstanding Postdoc Award

  • Cancer Genomics
  • Regulatory Genomics
  • Data Science
  • Machine Learning
  • Artificial Intelligence
  • Big Data

Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity

September 24, 2024
https://doi.org/10.1016/j.celrep.2024.114711

Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim, Takahiro Karasaki, Sophia Ward, Selvaraju Veeriah, Emma Colliver, Ariana Huebner, Abigail Bunkum, Mark S. Hill, Kristiana Grigoriadis, David A. Moore, James R. M. Black, Wing Kin Liu, Kerstin Thol, Oriol Pich, Thomas B. K. Watkins, Cristina Naceur-Lombardelli, Daniel E. Cook, Roberto Salgado, Gareth A. Wilson, Chris Bailey, Mihaela Angelova, Robert Bentham, Carlos Martínez-Ruiz, Christopher Abbosh, Andrew G. Nicholson, John Le Quesne, Dhruva Biswas, Rachel Rosenthal, Clare Puttick, Sonya Hessey, Claudia Lee, Paulina Prymas, Antonia Toncheva, Jon Smith, Wei Xing, Jerome Nicod, Gillian Price, Keith M. Kerr, Babu Naidu, Gary Middleton, Kevin G. Blyth, Dean A. Fennell, Martin D. Forster, Siow Ming Lee, Mary Falzon, Madeleine Hewish, Michael J. Shackcloth, Eric Lim, Sarah Benafif, Peter Russell, Ekaterini Boleti, Matthew G. Krebs, Jason F. Lester, Dionysis Papadatos-Pastos, Tanya Ahmad, Ricky M. Thakrar, David Lawrence, Neal Navani, Sam M. Janes, Caroline Dive, Fiona H. Blackhall, Yvonne Summers, Judith Cave, Teresa Marafioti, Javier Herrero, Sergio A. Quezada, Karl S. Peggs, Roland F. Schwarz, Peter Van Loo, Daniël M. Miedema, Nicolai J. Birkbak, Crispin T. Hiley, Allan Hackshaw, Simone Zaccaria, TRACERx Consortium, Mariam Jamal-Hanjani, Nicholas McGranahan & Charles Swanton

Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx

July 04, 2024
https://doi.org/10.1038/s41586-024-07738-w

Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

June 13, 2024
https://doi.org/10.1038/s41467-024-47606-9

Maja C Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H Schulte, Richard P Koche, Anton G Henssen, Roland F Schwarz, Kerstin Haase

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

May 17, 2024
https://www.biorxiv.org/content/10.1101/2023.01.21.525014v3.full.pdf

Ting Xie, Adi Danieli-Mackay, Mariachiara Buccarelli, Mariano Barbieri, Ioanna Papadionysiou, Q. Giorgio D’Alessandris, Claudia Robens, Nadine Übelmesser, Omkar Suhas Vinchure, Liverana Lauretti, Giorgio Fotia, Roland F. Schwarz, Xiaotao Wang, Lucia Ricci-Vitiani, Jay Gopalakrishnan, Roberto Pallini,Argyris Papantonis

Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

May 09, 2024
https://doi.org/10.1038/s41467-024-48053-2

BIFOLD Update| Aug 06, 2020

An overview of the current state of research in BIFOLD

Since the official announcement of the Berlin Institute for the Foundations of Learning and Data in January 2020, BIFOLD researchers achieved a wide array of advancements in the domains of Machine Learning and Big Data Management as well as in a variety of application areas by developing new Systems and creating impactfull publications. The following summary provides an overview of recent research activities and successes.

Machine Learning| Jun 04, 2020

Cloud computing contributes to cancer research

PCAWG, the largest cancer research consortium in the world, has set itself the task of improving our understanding of genetic mutations in tumors. A new study by the international research group, to which researchers in BIFOLD senior researcher Dr. Roland Schwarz’ group at the Max Delbrück Center for Molecular Medicine (MDC) substantially contributed, is now being published in the journal Nature.